Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. (Article, 2011) [WorldCat.org]
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Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging.
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Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging.

Author: Steven M Stufflebeam Affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA. sms@nmr.mgh.harvard.eduHesheng LiuJorge SepulcreNaoaki TanakaRandy L BucknerAll authors
Edition/Format: Article Article : English
Publication:Journal of neurosurgery, v114 n6 (201106): 1693-7
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Summary:
In patients with medically refractory epilepsy the accurate localization of the seizure onset zone is critical for successful surgical treatment. The object of this study was to investigate whether the degree of coupling of spontaneous brain activity as measured with functional connectivity MR imaging (fcMR imaging) can accurately identify and localize epileptic discharges. The authors studied 6 patients who  Read more...
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Document Type: Article
All Authors / Contributors: Steven M Stufflebeam Affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA. sms@nmr.mgh.harvard.edu; Hesheng Liu; Jorge Sepulcre; Naoaki Tanaka; Randy L Buckner; Joseph R Madsen
ISSN:0022-3085
Language Note: English
Unique Identifier: 728675997
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Abstract:

In patients with medically refractory epilepsy the accurate localization of the seizure onset zone is critical for successful surgical treatment. The object of this study was to investigate whether the degree of coupling of spontaneous brain activity as measured with functional connectivity MR imaging (fcMR imaging) can accurately identify and localize epileptic discharges. The authors studied 6 patients who underwent fcMR imaging presurgical mapping and subsequently underwent invasive electroencephalography. Focal regions of statistically significant increases in connectivity were identified in 5 patients when compared with an ad hoc normative sample of 300 controls. The foci identified by fcMR imaging overlapped the epileptogenic areas identified by invasive encephalography in all 5 patients. These results suggest that fcMR imaging may provide an effective high-spatial resolution and noninvasive method of localizing epileptic discharges in patients with refractory epilepsy.

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