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  E-mail Message: I thought you might be interested in this item at http://www.worldcat.org/oclc/107906622 Title: Functional connectivity networks are disrupted in left temporal lobe epilepsy. Publisher: ISBN/ISSN: 0364-5134 OCLC:107906622

  
  

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Functional connectivity networks are disrupted in left temporal lobe epilepsy.

Author:	AB Waites Affiliation: Brain Research Institute, Austin Health, Heidelberg West, Victoria, Australia.; RS Briellmann; MM Saling; DF Abbott; GD Jackson
Edition/Format:	Article : English
Publication:	Annals of neurology, 2006 Feb; 59(2): 335-43
Other Databases:	WorldCat; WorldCat
Summary:	OBJECTIVE: Functional connectivity maps the distributed network of brain regions fluctuating synchronously during a continuous brain state. This study sought to investigate whether patients with left temporal lobe epilepsy (TLE) differ from controls in their resting-state functional connectivity between typical language regions. METHODS: We studied 17 patients with left TLE, together with eight healthy controls, using seeded functional connectivity. Seed regions were defined using the regions of maximal activation and deactivation during a language functional magnetic resonance imaging (fMRI) task in a separate cohort of 30 controls. RESULTS: Language fMRI produced the expected activation pattern, which was not different between patients and controls. However, functional connectivity between language areas during rest was markedly different; whereas controls showed connectivity between each of the seed areas and the majority of the language areas, patients showed connectivity only with a few areas, particularly the seed area itself. This difference was significant in the direct comparison of patients and control connectivity maps. INTERPRETATION: We suggest that this reduced connectivity in left temporal lobe epilepsy may reflect a disturbance of the language network during resting state in patients and may be related to subtle language difficulties in this patient population.  Read more...
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